Response criteria for glioma

Response criteria for phase II studies of supratentorial malignant glioma.

We suggest "new" response criteria for phase II studies of supratentorial malignant glioma and favor rigorous criteria similar to those in medical oncology, with important modifications. Four response categories are proposed: complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). Response in this scheme is based on major changes in tumor size on the en...

Criteria for bronchodilator response.

Immune Response in Malignant Glioma

Objective: Malignant gliomas are primary brain tumors with excessive mortality and high resistance to chemotherapy and radiotherapy. The survival time for glioblastoma multiforme is about 6-12 months. As key pathogenetic mechanisms are recognized the massive necrosis, angiogenesis and hypoxia within the tumor, as well as the resistance to apoptosis. It is also suspected that altered immune resp...

Revised response criteria for malignant lymphoma.

PURPOSE Standardized response criteria are needed to interpret and compare clinical trials and for approval of new therapeutic agents by regulatory agencies. METHODS The International Working Group response criteria (Cheson et al, J Clin Oncol 17:1244, 1999) were widely adopted, but required reassessment because of identified limitations and the increased use of [18F]fluorodeoxyglucose-positr...

Ventilatory criteria for systemic inflammatory response syndrome.

Communications to the Editor clinical picture is similar to that produced by other organisms, such as mycobacteria, although Nocardia is also capable of inducing a granulomatous reaction in tissue. This gives rise to the possibility of making an erroneous diagnosis of tuberculosis, above all in areas such as Spain where this disease is relatively frequent. Although ceftriaxone has been shown to...